MUMBAI: Patients with diabetes are known to be more prone to heart attacks. Now, a study from University of Iowa has worked out why this happens.
Studying mice with diabetes, they realized that patients with the diabetes have higher levels of a heart enzyme called CaMKII (calcium/calmodulin-dependent protein kinase II). An analysis showed that heart rates in the diabetic mice slowed dramatically and, like humans with diabetes, the mice had double the death rate after a heart attack compared to non-diabetic mice.
The team studied the heart's pacemaker cells because most deaths showed abnormalities on the rhythm of the heart. "Many studies have shown that patients with diabetes are at especially high risk for dying from a myocardial infarction (heart attack). Our study provides new evidence that this excess mortality could involve a pathway where oxidized CaMKII enzyme plays a central role," the study's lead author Mark Anderson has been quoted as saying.
The study, published in the Journal of Clinical Investigation, found thatpacemaker cells had elevated levels of oxidized CaMKII enzyme and more cell death than pacemaker cells in non-diabetic mice. Interestingly, when the team blocked oxidation-based activation of the enzyme, fewer pacemaker cells died. The study thus shows that by reducing activation of the CaMKII enzyme in heart cells may reduce the risk of death due to heart attack in patients with diabetes.
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