HYDERABAD: Suffering from nagging eye infections. Your daily cup of coffee could fix the persistent eye problems.
A team of researchers from the school of chemistry led by Prof Ashwini Nangia has found that caffeine, a chemical substance present in coffee, could help in preparation of medicine to fight infections of the eye. They have formulated the medicine by co-crystallizing an antibiotic with caffeine. Rajesh Goud, research scholar, is part of Prof Nangia's team.
Sulfacetamide (SACT), a medicine commonly used for treatment of eye infections particularly conjunctivitis, is often lost when a person blinks. It is also washed away in tears. This leads to inconvenience and complications of applying larger and more frequent doses of SACT. Various schemes have been investigated, including trapping SACT in bioadhesive microspheres, to slow drug release and prevent its washout. But these either limited the drug's bioavailability (efficacy) or weren't suitable to market.
To solve the problem, Professor Nangia and his colleagues at UoH, looked to co-crystals. Crystallizing an existing drug with another safe substance can change the physico-chemical properties of a medicine without having to change the drug molecule itself. The team reasoned that replacing weaker hydrogen bonds in the crystals with stronger ones could lower the crystal's solubility and dissolution rate. A selection of molecules were therefore co-crystallized with SACT.
The identification of intermolecular interactions which can be altered by co-crystal formation is what makes this research noteworthy and stand out among such design strategies.
Caffeine proved to be one of the most successful, making the drug less soluble and the crystals denser — suggesting the molecules packed tighter together — compared to SACT alone, says Prof Nangia.
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