Triclosan, the anti-microbial chemical finds its way into human noses where it promotes the colonization of Staphylococcus aureus bacteria and could predispose some people to infection.
These findings were reported by researchers at the University of Michigan this week in a study published in mBio®, the online open-access journal of the American Society for Microbiology.
"It's really common in hand soaps, toothpastes and mouthwashes but there's no evidence it does a better job than regular soap," said Blaise Boles, senior study author and an assistant professor of molecular, cellular and developmental biology at the university . "This agent may have unintended consequences in our bodies. It could promote S. aureus nasal colonization, putting some people at increased risk for infection."
Staphylococcus aureus, popularly known as Staph, causes skin infections, boils and pimples, respiratory diseases, sinusitis etc. Its anti-biotic resistant strain called MRSA causes deadly infections, especially in institutional conditions like hospitals and prisons. Such infections are very difficult to treat.
Triclosan, a human-made compound used in a range of antibacterial personal care products such as soaps, toothpastes, kitchen surfaces, clothes and medical equipment, was found in nasal passages of 41% of adults sampled, according to a report by the American Society for Microbiology. A higher proportion of subjects with triclosan also had S. aureus colonization. S. aureus could promote infection in some populations such as people undergoing surgery.
Triclosan has been around for the past 40 years, according to Boles, and has been incorporated into many antibacterial household products within the past decade. Other studies have found traces of triclosan in human fluids including serum, urine and milk, and studies in mammals have found that high concentrations of triclosan can disrupt the endocrine system and decrease heart and skeletal muscle function.
Additional experiments found that S. aureus grown in the presence of triclosan was better able to attach to human proteins, and that rats exposed to triclosan were more susceptible to S. aureus nasal colonization.
"In light of the significant use of triclosan in consumer products and its widespread environmental contamination, our data combined with previous studies showing impacts of triclosan on the endocrine system and muscle function suggest that a reevaluation of triclosan in consumer products is urgently needed," the authors wrote.
The study was funded by the US National Institute of Allergy and Infectious Diseases.
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