MUMBAI: American scientists have tracked the evolution of one of the deadliest superbugs called Klebsiella pneumoniae. They hope it will pave the way for discovery of drugs that would be effective against the superbug, said the study which appeared online in the Proceedings of the National Academy of Sciences.
While researchers had previously thought that ST258 K pneumoniae strains spread from a single ancestor, the National Institute of Allergy and Infectious Diseases (NIAID) team showed that the strains arose from at least two different lineages. The key difference between the two groups lies in the genes involved in production of the bacterium's outer coat, which interacts with the human immune system.
ST258 K pneumoniae causes infections which kill approximately 600 people annually in the United States. It is resistant to most antibiotics, making treatment a difficult process.
Scientists from various organizations working for the NIAID team sequenced the complete genomes of ST258 K pneumoniae strains collected from two patients in New Jersey hospitals. By comparing these genomes with gene sequences from an additional 83 clinical ST258 K pneumoniae isolates, the scientists found that the strains divided broadly into two distinct groups, each with its own evolutionary history.
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