They believe it serves as a natural back-up mechanism during faulty cell division, preventing some cells from going down a path that can lead to cancer.
"If we could promote this new form of cell division, which we call lerokinesis/cytofission, we may be able to prevent some cancers from developing," claims lead researcher Choudharya, who is a cancer researcher in the department of medicine at UW School of Medicine and Public Health.
She did her masters from department of microbiology and PhD from department of biotechnology, Panjab University.
This finding is published in a scientific journal "Proceedings of National Academy of Sciences of the United States of America in 2013" and also presented at the biggest international cell biology conference of the American Society for Cell Biology in San Francisco, California, USA.
About 14% of breast cancers and 35% of pancreatic cancers have three or more sets of chromosomes, instead of the usual two sets. Many other cancers have cells containing defective chromosomes rather than too many or too few.
"Our goal in the laboratory has been to find ways to develop new treatment strategies for breast cancers with too many chromosome sets," she says.
The original goal of the current study was to make human cells that have extra chromosome sets. But after following the accepted recipe, the researchers unexpectedly observed the new form of cell division.
Until now, Choudhary and most cell biologists accepted a century-old hypothesis developed by German biologist Theodor Boveri, who studied sea urchin eggs. Boveri surmised that faulty cell division led to cells with abnormal chromosome sets, and then to the unchecked cell growth that defines cancer. With accumulated evidence over the years, most scientists have come to accept the hypothesis.
Normal cell division is at the heart of an organism's ability to grow from a single fertilized egg into a fully developed individual. More than a million-million rounds of division must take place for this to occur. In each division, one mother cell becomes two daughter cells. Even in a fully grown adult, many kinds of cells are routinely remade through cell division.
Collaborators on the project include Dr Mark Burkard MD, PhD, UW, assistant professor at School of Medicine and Public health; Dr Beth Weaver, UW assistant professor of cell and regenerative biology; Robert Lera; Dr Melissa Martowicz and Dr Jennifer Laffin.
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